Reproduction Abstracts

Introduction: Preeclampsia is a pregnancy-specific disease characterized by concurrent development of hypertension, proteinuria, and oxidative stress in the placenta. Preeclampsia-like genetic models were also developed by modification of preeclampsia-related genes, such as catechol-O-methyltranferase (COMT).Materials and methods: In this study, we induced COMT inhibition in mice during pregnancy to reproduce physiological conditions associated ...